Developing models based on a particular sign or symptom of schizophrenia has been one approach. Sdy mice have homozygous mutations to DTNBP1, and lack the ability to produce dysbindin, heterozygous mutants can be produced by crossing sdy mice with a strain of normal mice. Amsterdam: Elsevier Science. Research into the psychotic disorder of schizophrenia , involves multiple animal models as a tool, including in the pre-clinical development of drugs. Rodent models of schizophrenia mostly display symptoms analogous to the positive symptoms of schizophrenia , with some models also having symptoms similar to the negative symptoms. The antipsychotics clozapine and haloperidol reverse the effects of amphetamine on attention in rats. Knockout mice in which the reelin gene is disrupted are called reeler mice. NVHL rats mimic many of the symptoms of schizophrenia in detail.
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