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Thus, there is an urgent requirement to explore and seek the best combination in order to obtain the best treatment effect 1. This is in contrast from previous studies 26 , 27 , which reported that inhibition of ILK leads to tumor cells stagnating in the G1 phase. The experiment was repeated three times. Mice were sacrificed at 28 days after the first hyperthermia. Acknowledgements The present study was supported by the project in Sichuan Province Scientific and Technological Support grant no. Reverse transcription-quantitative polymerase chain reaction RT-qPCR analysis Each experiment was conducted in duplicate and repeated 3 times. D The figures of the NC group were same as the control group. The relevant mechanisms were analyzed, and an objective basis was provided for gene silencing therapy and hyperthermia combined treatment of OSCC. Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3beta in the regulation of HSF-1 activity.

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